Structure of PDB 7lwb Chain A

Receptor sequence
>7lwbA (length=182) Species: 9606 (Homo sapiens) [Search protein sequence]
SHMAKTYDYLFKLLLIGDSGVGKTCVLFRFSEDAFNSTFISTIGIDFKIR
TIELDGKRIKLQIWDTAGLERFRTITTAYYRGAMGIMLVYDITNEKSFDN
IRNWIRNIEEHASADVEKMILGNKCDVNDKRQVSKERGEKLALDYGIKFM
ETSAKANINVENAFFTLARDIKAKMDKKLEGN
3D structure
PDB7lwb Dual arginine recognition of LRRK2 phosphorylated Rab GTPases.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP A S17 G18 V19 G20 K21 T22 C23 F33 S35 F37 S39 T40 G66 N121 K122 D124 S151 K153 S19 G20 V21 G22 K23 T24 C25 F35 S37 F39 S41 T42 G68 N123 K124 D126 S153 K155
BS02 MG A T22 T40 T24 T42
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:7lwb, PDBe:7lwb, PDBj:7lwb
PDBsum7lwb
PubMed33887226
UniProtP61006|RAB8A_HUMAN Ras-related protein Rab-8A (Gene Name=RAB8A)

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