Structure of PDB 7lwa Chain A

Receptor sequence
>7lwaA (length=258) Species: 9606 (Homo sapiens) [Search protein sequence]
LSPMERFHLKYLYVTDLAEQNWCELQTAYGKELPGPVTTKEDAWAIKFLN
ILLLIPTLQSEGHIREFPVFGEVEGVLLVGVIDELHYTAKGELELAELKT
RRRPMLPLEAQKKKDCFQVSLYKYIFDAMVQGKVTPASLIHHTKLCLEKP
LGPSVLRHAQQGGFSVKSLGDLMELVFLSLTLSDLPVIDILKIEYIHQET
ATVLGTEIVAFKEKEVRAKVQHYMAYWMGHREPQGVDVEEAWKCRTCTYA
DICEWRKG
3D structure
PDB7lwa EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart.
ChainA
Resolution2.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A Y82 V83 T84 E196 K198 Q217 Y221 Y13 V14 T15 E97 K99 Q118 Y122
BS02 SF4 A C92 L94 Q95 C343 C346 A349 C352 C23 L25 Q26 C244 C247 A250 C253
BS03 MG A D182 E196 D83 E97
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004527 exonuclease activity
GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity
GO:0045145 single-stranded DNA 5'-3' DNA exonuclease activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006281 DNA repair
GO:0036297 interstrand cross-link repair
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7lwa, PDBe:7lwa, PDBj:7lwa
PDBsum7lwa
PubMed34197737
UniProtQ9H790|EXO5_HUMAN Exonuclease V (Gene Name=EXO5)

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