Structure of PDB 7lw8 Chain A

Receptor sequence
>7lw8A (length=260) Species: 9606 (Homo sapiens) [Search protein sequence]
ILSPMERFHLKYLYVTDLATQNWCELQTAYGKELPGFLVPVTTKEDAWAI
KFLNILLLIPTLQSEGHIREFPVFGEVEGVLLVGVIDELHYTAKGELELA
ELKTRRRPMLPLEAQKKKDCFQVSLYKYIFDAMVQGKVTPASLIHHTKLC
LEKPLGPSVLRHAQQGGFSVKSLGDLMELVFLSLTLSDLPVIDILKIEYI
HQETATVLGTEIVAFKEKEVRAKVQHYMAYWMGHREPQGVDVEEAWKCRT
CTYADICEWR
3D structure
PDB7lw8 EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart.
ChainA
Resolution2.88 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A L78 Y80 Y82 V83 T84 W91 K146 V178 G179 V180 K198 T199 R200 R201 R202 Q210 K213 Y221 R344 T345 L10 Y12 Y14 V15 T16 W23 K51 V83 G84 V85 K103 T104 R105 R106 R107 Q115 K118 Y126 R249 T250
BS02 SF4 A C92 L94 Q95 C343 C346 C352 C24 L26 Q27 C248 C251 C257
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004527 exonuclease activity
GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity
GO:0045145 single-stranded DNA 5'-3' DNA exonuclease activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006281 DNA repair
GO:0036297 interstrand cross-link repair
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7lw8, PDBe:7lw8, PDBj:7lw8
PDBsum7lw8
PubMed34197737
UniProtQ9H790|EXO5_HUMAN Exonuclease V (Gene Name=EXO5)

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