Structure of PDB 7lw6 Chain A

Receptor sequence
>7lw6A (length=180) Species: 655278 (Influenza A virus (A/Luxembourg/43/2009(H1N1))) [Search protein sequence]
PRGSHMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAATCTHLEVC
FMYSDGGSKHRFEIIEGRDRIMAWTVVNSICNTTGVEKPKFLPDLYDYKE
NRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLD
EESRARIKTRLFTIRQEMASRSLWDSFRQS
3D structure
PDB7lw6 Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential.
ChainA
Resolution2.38 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RLT A H41 F105 L106 D108 E119 H46 F91 L92 D94 E105
BS02 QQ4 A M12 F46 M17 F51
BS03 MN A H41 D108 E119 I120 H46 D94 E105 I106
BS04 MN A E80 P107 D108 E66 P93 D94
Gene Ontology
Biological Process
GO:0039694 viral RNA genome replication

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7lw6, PDBe:7lw6, PDBj:7lw6
PDBsum7lw6
PubMed36603507
UniProtC6H0Y9

[Back to BioLiP]