Structure of PDB 7lw1 Chain A

Receptor sequence

>7lw1A (length=744) Species: 9606 (Homo sapiens) [Search protein sequence]

ASGAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVE
GGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHGI
TNLCVIGGDGSLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAG
LVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGR
HCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNII
IIAEGAIDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDR
ILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPLMECVQMTKEVQK
AMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPKEKSNFSLAILNVGAP
AAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLG
RGGSMLGTKRTLPKGQLESIVENIRIYGIHALLVVGGFEAYEGVLQLVEA
RGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSAS
GTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEH
MTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGH
LQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANAPDSACVI
GLKKKAVAFSPVTELKKDTDFEHRMPREQWWLSLRLMLKMLAQY

3D structure

PDB

7lw1 Selective activation of PFKL suppresses the phagocytic oxidative burst.

Chain

Resolution

2.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.1.11: 6-phosphofructokinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	YG1	A	M174 F308 I311 K315 N341 F537 D542 V545 Y578 F670 W740 L744	M164 F298 I301 K305 N331 F527 D532 V535 Y568 F660 W730 L734
BS02	FBP	A	A409 R470 S529 M572 E628 H660 R734	A399 R460 S519 M562 E618 H650 R724
BS03	F6P	A	I165 D166 M208 R210 E264 H298 R301	I155 D156 M198 R200 E254 H288 R291
BS04	ADP	A	R88 C89 T93 G118 G120 S121 G124 I127	R78 C79 T83 G108 G110 S111 G114 I117
BS05	FBP	A	R565 R654	R555 R644
BS06	F6P	A	R201 R292	R191 R282

Gene Ontology

	Molecular Function
GO:0003872	6-phosphofructokinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016208	AMP binding
GO:0016301	kinase activity
GO:0019900	kinase binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding
GO:0048029	monosaccharide binding
GO:0070061	fructose binding
GO:0070095	fructose-6-phosphate binding

	Biological Process
GO:0006002	fructose 6-phosphate metabolic process
GO:0006096	glycolytic process
GO:0009749	response to glucose
GO:0016310	phosphorylation
GO:0030388	fructose 1,6-bisphosphate metabolic process
GO:0046676	negative regulation of insulin secretion
GO:0061615	glycolytic process through fructose-6-phosphate
GO:0061621	canonical glycolysis

	Cellular Component
GO:0005576	extracellular region
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005945	6-phosphofructokinase complex
GO:0016020	membrane
GO:0034774	secretory granule lumen
GO:0070062	extracellular exosome
GO:1904813	ficolin-1-rich granule lumen

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7lw1, PDBe:7lw1, PDBj:7lw1
PDBsum	7lw1
PubMed	34320407
UniProt	P17858\|PFKAL_HUMAN ATP-dependent 6-phosphofructokinase, liver type (Gene Name=PFKL)

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