Structure of PDB 7lvi Chain A

Receptor sequence
>7lviA (length=294) Species: 10090 (Mus musculus) [Search protein sequence]
YIGRVFGIGRQQVTVDEVLAEGGFALVFLVRTSNGVKCALKRMFVNNEHD
LQVCKREIQIMRDLGHKNIVGYIDSSINNVSDVWEVLILMDFCRGGQVVN
LMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHD
RGHYVLCDFGSATNKFQNPQAEGVNAVEDEIKKYTTLSYRAPEMVNLYSG
KIITTKADIWALGCLLYKLCYFTLPFGESQVAICDGSFTIPDNSRYSQDM
HCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPVPNVQNSPIP
3D structure
PDB7lvi Discovery, Structure-Activity Relationships, and In Vivo Evaluation of Novel Aryl Amides as Brain Penetrant Adaptor Protein 2-Associated Kinase 1 (AAK1) Inhibitors for the Treatment of Neuropathic Pain.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YFY A E54 G55 A58 V60 A72 V104 N181 L183 C193 D194 E21 G22 A25 V27 A39 V70 N145 L147 C157 D158
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7lvi, PDBe:7lvi, PDBj:7lvi
PDBsum7lvi
PubMed34270254
UniProtQ3UHJ0|AAK1_MOUSE AP2-associated protein kinase 1 (Gene Name=Aak1)

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