Structure of PDB 7lv3 Chain A

Receptor sequence
>7lv3A (length=601) Species: 9606 (Homo sapiens) [Search protein sequence]
RTKRQAISAEPTAFDIQDLSHVTLPFYPKSPQSKDLIKEAILDNDFMKNL
ELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKL
CTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLI
KHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDT
FFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIA
AEAVTCLVIDRDSFKHLIAEAKAKYEAEAAFFANLKLSDFNIIDTLGVGG
FGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDF
IVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVE
AFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCG
TPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNII
LRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFE
GFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPPDDNSGWDID
F
3D structure
PDB7lv3 An auto-inhibited state of protein kinase G and implications for selective activation.
ChainA
Resolution2.41 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.12: cGMP-dependent protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A N504 D517 N419 D432
BS02 ANP A G382 G384 G385 F386 V389 A403 K405 C456 E460 K501 E503 I506 D517 G297 G299 G300 F301 V304 A318 K320 C371 E375 K416 E418 I421 D432
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004692 cGMP-dependent protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7lv3, PDBe:7lv3, PDBj:7lv3
PDBsum7lv3
PubMed35929723
UniProtQ13976|KGP1_HUMAN cGMP-dependent protein kinase 1 (Gene Name=PRKG1)

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