Structure of PDB 7lub Chain A

Receptor sequence
>7lubA (length=460) Species: 9606 (Homo sapiens) [Search protein sequence]
NSFRIEYDTFGELKVPNDKYYGAQTVRSTMNFKIGGVTERMPTPVIKAFG
ILKRAAAEVNQDYGLDPKIANAIMKAADEVAEGKLNDHFPLVVWQTGSGT
QTNMNVNEVISNRAIEMLGGELGSKIPVHPNDHVNKSQSSNDTFPTAMHI
AAAIEVHEVLLPGLQKLHDALDAKSKEFAQIIKIGRTHTQDAVPLTLGQE
FSGYVQQVKYAMTRIKAAMPRIYELAAGGTAVGTGLNTRIGFAEKVAAKV
AALTGLPFVTAPNKFEALAAHDALVELSGAMNTTACSLMKIANDIRFLGS
GPRSGLGELILPENEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHVAVTVG
GSNGHFELNVFKPMMIKNVLHSARLLGDASVSFTENCVVGIQANTERINK
LMNESLMLVTALNPHIYDKAAKIAKTAHKNGSTLETIELGYLTAEQFDEW
VKPKDMLGPK
3D structure
PDB7lub Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase.
ChainA
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.2.1.2: fumarate hydratase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 APO A T147 S186 S187 N188 T100 S139 S140 N141
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004333 fumarate hydratase activity
GO:0005515 protein binding
GO:0016829 lyase activity
Biological Process
GO:0006099 tricarboxylic acid cycle
GO:0006106 fumarate metabolic process
GO:0006108 malate metabolic process
GO:0006281 DNA repair
GO:0048873 homeostasis of number of cells within a tissue
GO:0120162 positive regulation of cold-induced thermogenesis
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7lub, PDBe:7lub, PDBj:7lub
PDBsum7lub
PubMed36893255
UniProtP07954|FUMH_HUMAN Fumarate hydratase, mitochondrial (Gene Name=FH)

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