Structure of PDB 7lt2 Chain A

Receptor sequence
>7lt2A (length=387) Species: 7070 (Tribolium castaneum) [Search protein sequence]
ENILNDINKRFISLPEEDVRGNKQILESVLRTFVEQMKTQDPLFKALFRR
VFYGGSFYDGLKVGKPEEFDLDILLHIPIYAQPVLNESNVPGFVWLKLNN
LDGWLRQPEGRVYKDFRKKFLADNDFLDTGKTLRWMESLVQKTLNTLPWV
NNATCELTNEFGTFHINWWKGGPAMTLGISHSSGEKIMDVDLVACFVFSG
DKWPINGYRSNPFPSTKPEFFIVPKKPPVNPQGRYWSLSFQEQERVLIDN
KNRLKPAVKLIKKLKEKTHPNIASYYIKTVFLHIIEQKDQSFWNKSLREV
FMTTLREYNEFIADQSIPYYWCRKNNLIGHLAPITLNNISNRIGYIIKDI
ENNPENIAKHLLTKEEYTKYIQGEDVMAEALPALPAS
3D structure
PDB7lt2 cGAS-like receptors sense RNA and control 3'2'-cGAMP signalling in Drosophila.
ChainA
Resolution1.58 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A I289 E290 K292 I285 E286 K288
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
GO:0140700 3',2'-cyclic GMP-AMP synthase activity
Biological Process
GO:0045087 innate immune response
GO:0051607 defense response to virus
GO:1902615 immune response involved in response to exogenous dsRNA

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Molecular Function
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Biological Process
External links
PDB RCSB:7lt2, PDBe:7lt2, PDBj:7lt2
PDBsum7lt2
PubMed34261127
UniProtD6WI29|CGLR_TRICA Cyclic GMP-AMP synthase-like receptor (Gene Name=TcasGA2_TC003965)

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