Structure of PDB 7ls3 Chain A

Receptor sequence

>7ls3A (length=429) Species: 9606 (Homo sapiens) [Search protein sequence]

SRYEHIPGPPVLQDVFLDWAKKYGPVVRVNVFKTSVIVTSPESVKKFLMS
TKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSS
LVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGM
ETSMLLGAQKPLSQAVKLMLEGITAKRKQLREVRESIRFLRQVGRDWVQR
RREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANH
LAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKES
LRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLT
FNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEF
RLVPGQRFGLQEQATLKPLDPVLCTLRPR

3D structure

PDB

7ls3 Discovery of Soticlestat, a Potent and Selective Inhibitor for Cholesterol 24-Hydroxylase (CH24H).

Chain

Resolution

2.15 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.14.14.25: cholesterol 24-hydroxylase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	HEM	A	K104 Y109 L125 V126 W134 R138 F299 A302 G303 T306 A367 T370 P429 F430 S431 R435 C437 I438 G439 A443	K55 Y60 L76 V77 W85 R89 F239 A242 G243 T246 A307 T310 P369 F370 S371 R375 C377 I378 G379 A383
BS02	YCJ	A	L112 F121 A302 T306 W368 G369 A474 T475	L63 F72 A242 T246 W308 G309 A414 T415

Gene Ontology

	Molecular Function
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0008395	steroid hydroxylase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0033781	cholesterol 24-hydroxylase activity
GO:0046872	metal ion binding
GO:0062184	testosterone 16-beta-hydroxylase activity

	Biological Process
GO:0006699	bile acid biosynthetic process
GO:0006707	cholesterol catabolic process
GO:0006805	xenobiotic metabolic process
GO:0007399	nervous system development
GO:0008203	cholesterol metabolic process
GO:0008207	C21-steroid hormone metabolic process
GO:0016125	sterol metabolic process
GO:0042448	progesterone metabolic process
GO:1900271	regulation of long-term synaptic potentiation
GO:1903044	protein localization to membrane raft

	Cellular Component
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0030425	dendrite
GO:0042995	cell projection
GO:0045202	synapse
GO:0098793	presynapse
GO:0098794	postsynapse

View graph for
Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7ls3, PDBe:7ls3, PDBj:7ls3
PDBsum	7ls3
PubMed	34387987
UniProt	Q9Y6A2\|CP46A_HUMAN Cholesterol 24-hydroxylase (Gene Name=CYP46A1)

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