Structure of PDB 7lqd Chain A

Receptor sequence
>7lqdA (length=269) Species: 9606 (Homo sapiens) [Search protein sequence]
FQSMSVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQT
LDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLK
KKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLID
FGIANQMQPDTTSVKDSQVGTVNYMPPEAIKDMKISPKSDVWSLGCILYY
MTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDP
KQRISIPELLAHPYVQIQT
3D structure
PDB7lqd Development of the First Covalent Monopolar Spindle Kinase 1 (MPS1/TTK) Inhibitor.
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.12.1: dual-specificity kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YB4 A I531 S537 V539 Q541 K553 C604 G605 N606 A651 L654 I663 M671 I17 S23 V25 Q27 K39 C90 G91 N92 A137 L140 I149 M157
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7lqd, PDBe:7lqd, PDBj:7lqd
PDBsum7lqd
PubMed35167750
UniProtP33981|TTK_HUMAN Dual specificity protein kinase TTK (Gene Name=TTK)

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