Structure of PDB 7lpy Chain A

Receptor sequence
>7lpyA (length=200) Species: 9606 (Homo sapiens) [Search protein sequence]
MSFPPQRYHYFLVLDFEATCDKPQIHPQEIIEFPILKLNGRTMEIESTFH
MYVQPVVHPQLTPFCTELTGIIQAMVDGQPSLQQVLERVDEWMAKEGLLD
PNVKSIFVTCGDWDLKVMLPGQCQYLGLPVADYFKQWINLKKAYSFAMGC
WPKNGLLDMNKGLSLQHIGRPHSGIDDCKNIANIMKTLAYRGFIFKQTSK
3D structure
PDB7lpy Crystal structures and ribonuclease activity of the Flavivirus host factor ERI3 that is involved in viral RNA synthesis define the ERI subfamily of structure-specific 3' - 5' exoribonucleases
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP A D150 E152 A153 C155 K157 Q159 F199 L203 W248 D15 E17 A18 C20 K22 Q24 F64 L68 W113
BS02 MN A D150 E152 D312 D15 E17 D177
Gene Ontology
Molecular Function
GO:0000175 3'-5'-RNA exonuclease activity
GO:0003676 nucleic acid binding

View graph for
Molecular Function
External links
PDB RCSB:7lpy, PDBe:7lpy, PDBj:7lpy
PDBsum7lpy
PubMed
UniProtO43414|ERI3_HUMAN ERI1 exoribonuclease 3 (Gene Name=ERI3)

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