Structure of PDB 7lp8 Chain A

Receptor sequence
>7lp8A (length=183) Species: 655278 (Influenza A virus (A/Luxembourg/43/2009(H1N1))) [Search protein sequence]
LVPRGSHMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAATCTHLE
VCFMYSDGGSKHRFEIIEGRDRIMAWTVVNSICNTTGVEKPKFLPDLYDY
KENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYT
LDEESRARIKTRLFTIRQEMASRSLWDSFRQSE
3D structure
PDB7lp8 Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential.
ChainA
Resolution2.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YAD A Y24 H41 D108 E119 I120 Y130 K134 Y31 H48 D96 E107 I108 Y118 K122
BS02 QQ4 A N10 F46 G81 N17 F53 G69
BS03 MN A H41 D108 E119 I120 H48 D96 E107 I108
BS04 MN A E80 D108 E68 D96
Gene Ontology
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:7lp8, PDBe:7lp8, PDBj:7lp8
PDBsum7lp8
PubMed
UniProtC6H0Y9

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