Structure of PDB 7lp7 Chain A

Receptor sequence
>7lp7A (length=180) Species: 655278 (Influenza A virus (A/Luxembourg/43/2009(H1N1))) [Search protein sequence]
RGSHMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCF
MYSDGGSKHRFEIIEGRDRIMAWTVVNSICNTTGVEKPKFLPDLYDYKEN
RFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDE
ESRARIKTRLFTIRQEMASRSLWDSFRQSE
3D structure
PDB7lp7 Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential.
ChainA
Resolution2.5 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YAD A A20 Y24 E26 I38 H41 E80 D108 E119 A24 Y28 E30 I42 H45 E65 D93 E104
BS02 QQ4 A M12 F46 M16 F50
BS03 MN A H41 D108 E119 I120 H45 D93 E104 I105
BS04 MN A E80 D108 E65 D93
Gene Ontology
Biological Process
GO:0039694 viral RNA genome replication

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7lp7, PDBe:7lp7, PDBj:7lp7
PDBsum7lp7
PubMed
UniProtC6H0Y9

[Back to BioLiP]