Structure of PDB 7lp2 Chain A

Receptor sequence
>7lp2A (length=33) Species: 9606 (Homo sapiens) [Search protein sequence]
GLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIM
3D structure
PDB7lp2 Interactions between AMOT PPxY motifs and NEDD4L WW domains function in HIV-1 release.
ChainA
Resolution1.88 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.26: HECT-type E3 ubiquitin transferase.
2.3.2.36: RING-type E3 ubiquitin transferase (cysteine targeting).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A D396 Y402 V404 H406 R409 T411 T412 W413 D11 Y17 V19 H21 R24 T26 T27 W28
BS02 peptide A K398 R400 W413 K13 R15 W28
External links
PDB RCSB:7lp2, PDBe:7lp2, PDBj:7lp2
PDBsum7lp2
PubMed34284061
UniProtQ96PU5|NED4L_HUMAN E3 ubiquitin-protein ligase NEDD4-like (Gene Name=NEDD4L)

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