Structure of PDB 7lm4 Chain A

Receptor sequence
>7lm4A (length=183) Species: 641501 (Influenza A virus (A/California/04/2009(H1N1))) [Search protein sequence]
LVPRGSHMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAATCTHLE
VCFMYSDGGSKHRFEIIEGRDRIMAWTVVNSICNTTGVEKPKFLPDLYDY
KENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYT
LDEESRARIKTRLFTIRQEMASRSLWDSFRQSE
3D structure
PDB7lm4 Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential.
ChainA
Resolution2.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A H41 D108 E119 I120 H48 D96 E107 I108
BS02 MN A E80 D108 E68 D96
BS03 Y5V A Y24 K34 A37 H41 E80 D108 E119 Y31 K41 A44 H48 E68 D96 E107
BS04 QQ4 A M12 F46 M19 F53
Gene Ontology
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:7lm4, PDBe:7lm4, PDBj:7lm4
PDBsum7lm4
PubMed36603507
UniProtC3W5S0

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