Structure of PDB 7ll5 Chain A

Receptor sequence
>7ll5A (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]
DPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDGEVVAVKKLQHSTEEH
LRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYL
QKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVK
IGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFG
VVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRP
DGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
3D structure
PDB7ll5 High-resolution crystal structure of human JAK2 kinase domain (JH1) bound to PN5-150.
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y5G A L855 G856 K857 V863 A880 M929 E930 Y931 L932 G935 R980 N981 L983 G993 D994 L16 G17 K18 V24 A39 M88 E89 Y90 L91 G94 R139 N140 L142 G152 D153
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7ll5, PDBe:7ll5, PDBj:7ll5
PDBsum7ll5
PubMed
UniProtO60674|JAK2_HUMAN Tyrosine-protein kinase JAK2 (Gene Name=JAK2)

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