Structure of PDB 7liu Chain A

Receptor sequence

>7liuA (length=442) Species: 9606 (Homo sapiens) [Search protein sequence]

DWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSD
VEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAF
LLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYE
EARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERG
KIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSAT
FPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDL
LNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEAL
HQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGR
VGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAY

3D structure

PDB

7liu DDX3X bound to ATP analog and remodeled RNA:DNA hybrid

Chain

Resolution

3.001 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	P274 T275 R276 G302 G303 T323 P324 G325 R326 D329 G356 F357 Q360 E449 T450 K451 H472 G473 R480 T498 A499 V500 E524	P140 T141 R142 G168 G169 T189 P190 G191 R192 D195 G222 F223 Q226 E315 T316 K317 H338 G339 R346 T364 A365 V366 E390
BS02	08T	A	F160 Y200 T204 Q207 T226 G227 S228 G229 K230 T231 D506 R531 R534	F26 Y66 T70 Q73 T92 G93 S94 G95 K96 T97 D372 R397 R400

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003724	RNA helicase activity
GO:0005524	ATP binding

View graph for
Molecular Function

External links

PDB	RCSB:7liu, PDBe:7liu, PDBj:7liu
PDBsum	7liu
PubMed
UniProt	O00571\|DDX3X_HUMAN ATP-dependent RNA helicase DDX3X (Gene Name=DDX3X)

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