Structure of PDB 7lia Chain A

Receptor sequence

>7liaA (length=539) Species: 9606 (Homo sapiens)

RETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFG
GIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNT
IMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPA
EEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSG
KVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWID
AAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFV
IFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFF
LMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSL
VTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEM
LGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILG
YCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETP

3D structure

• PDB: 7lia Illumination of serotonin transporter mechanism and role of the allosteric site.
• Chain: A
• Resolution: 3.3 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	SRO	A	I172 A173 F341 T439 G442	I94 A95 F263 T361 G364
BS02	CL	A	Y121 Q332 S336 S372	Y43 Q254 S258 S294
BS03	NA	A	A96 D98 N101 S336 N368	A18 D20 N23 S258 N290
BS04	NA	A	G94 V97 L434 D437	G16 V19 L356 D359
BS05	SRO	A	E494 Y495 P499 F556 S559 P561 Y579	E416 Y417 P421 F478 S481 P483 Y501
BS06	CLR	A	V86 Y289 S293 V374	V8 Y211 S215 V296

Gene Ontology

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:7lia, PDBe:7lia, PDBj:7lia
• PDBsum: 7lia
• PubMed: 34851672
• UniProt: P31645|SC6A4_HUMAN Sodium-dependent serotonin transporter (Gene Name=SLC6A4)