Structure of PDB 7lgw Chain A

Receptor sequence
>7lgwA (length=680) Species: 9606 (Homo sapiens) [Search protein sequence]
TQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNIIY
MFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFG
LYSSFYPVIMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGV
NATNGTEARDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRG
FTTAAAVHVFTSMLKYLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSL
GVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTGISAGFNLKES
YNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLA
NKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQL
AGCLASLMILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFW
RTSKIELTIWLTTFVSSLFLGLDYGLITAVIIALLTVIYRTQSPSYKVLG
KLPETDVYIDIDAYEEVKEIPGIKIFQINAPIYYANSDLYSNALKRKTGV
NPAVIMGARRKAMRKYAKVKYPPIVIKSTFPEEMQRFMPPGDNVHTVILD
FTQVNFIDSVGVKTLAGIVKEYGDVGIYVYLAGCSAQVVNDLTRNRFFEN
PALWELLFHSIHDAVLGSQLREALAEQEAS
3D structure
PDB7lgw Molecular mechanism of prestin electromotive signal amplification.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR A Y486 I493 I494 Y474 I481 I482
Gene Ontology
Molecular Function
GO:0008271 secondary active sulfate transmembrane transporter activity
GO:0015106 bicarbonate transmembrane transporter activity
GO:0015108 chloride transmembrane transporter activity
GO:0015116 sulfate transmembrane transporter activity
GO:0019531 oxalate transmembrane transporter activity
GO:0030507 spectrin binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0140900 chloride:bicarbonate antiporter activity
Biological Process
GO:0002931 response to ischemia
GO:0006821 chloride transport
GO:0007605 sensory perception of sound
GO:0008360 regulation of cell shape
GO:0009410 response to xenobiotic stimulus
GO:0009751 response to salicylic acid
GO:0010996 response to auditory stimulus
GO:0015701 bicarbonate transport
GO:0015755 fructose transmembrane transport
GO:0019532 oxalate transport
GO:0034220 monoatomic ion transmembrane transport
GO:0034766 negative regulation of monoatomic ion transmembrane transport
GO:0035864 response to potassium ion
GO:0042391 regulation of membrane potential
GO:0045793 positive regulation of cell size
GO:0055085 transmembrane transport
GO:0090102 cochlea development
GO:0097066 response to thyroid hormone
GO:0098656 monoatomic anion transmembrane transport
GO:1902074 response to salt
GO:1902358 sulfate transmembrane transport
GO:1902476 chloride transmembrane transport
GO:2000147 positive regulation of cell motility
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016328 lateral plasma membrane
GO:0120249 lateral wall of outer hair cell

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7lgw, PDBe:7lgw, PDBj:7lgw
PDBsum7lgw
PubMed34390643
UniProtP58743|S26A5_HUMAN Prestin (Gene Name=SLC26A5)

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