Structure of PDB 7lgi Chain A

Receptor sequence
>7lgiA (length=169) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
CLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQI
KRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQ
GVDDAFYTLVREIRKHKEK
3D structure
PDB7lgi Antipsychotic phenothiazine drugs bind to KRAS in vitro.
ChainA
ResolutionN/A
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A G13 G15 K16 S17 A18 F28 D30 Y32 P34 N116 A146 G13 G15 K16 S17 A18 F28 D30 Y32 P34 N116 A146
BS02 MG A S17 D57 S17 D57
BS03 P2Z A K5 V7 S39 R41 D54 L56 Y71 T74 K5 V7 S39 R41 D54 L56 Y71 T74
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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External links
PDB RCSB:7lgi, PDBe:7lgi, PDBj:7lgi
PDBsum7lgi
PubMed34176062
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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