Structure of PDB 7lft Chain A

Receptor sequence
>7lftA (length=450) Species: 9606 (Homo sapiens) [Search protein sequence]
VVIDPSGNTYYNWLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDY
VSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIP
TDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVM
YIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYW
STLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNA
ARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLK
YLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDY
ICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGS
KAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMK
3D structure
PDB7lft Structural mechanisms of gating and selectivity of human rod CNGA1 channel.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR A L192 Y196 H312 L345 Y349 L37 Y41 H157 L190 Y194
BS02 CLR A M177 M182 Y196 W200 M22 M27 Y41 W45
BS03 CPL A Q286 Y306 I310 Q131 Y151 I155
BS04 CPL A I184 A187 C188 Y267 E269 L272 V317 S320 K323 I29 A32 C33 Y112 E114 L117 V162 S165 K168
BS05 CPL A R371 D372 S373 V376 L383 R216 D217 S218 V221 L228
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:7lft, PDBe:7lft, PDBj:7lft
PDBsum7lft
PubMed33651975
UniProtP29973|CNGA1_HUMAN Cyclic nucleotide-gated channel alpha-1 (Gene Name=CNGA1)

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