Structure of PDB 7lfc Chain A

Receptor sequence
>7lfcA (length=414) Species: 9606 (Homo sapiens) [Search protein sequence]
SLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVH
CLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQ
NVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVT
WVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTD
AGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQV
VLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVP
MIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLT
VKDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHENE
DIYKLAYEIIDQFF
3D structure
PDB7lfc Differential recognition of canonical NF-kappa B dimers by Importin alpha 3.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K97 S100 D102 R103 P105 W137 N141 S144 G145 T150 Q176 W179 N183 G186 D187 N219 W222 N226 R229 R306 K26 S29 D31 R32 P34 W66 N70 S73 G74 T79 Q105 W108 N112 G115 D116 N148 W151 N155 R158 R235
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008139 nuclear localization sequence binding
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006606 protein import into nucleus
GO:0006607 NLS-bearing protein import into nucleus
GO:0010467 gene expression
GO:0014046 dopamine secretion
GO:0015031 protein transport
Cellular Component
GO:0005634 nucleus
GO:0005643 nuclear pore
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0031965 nuclear membrane
GO:0042564 NLS-dependent protein nuclear import complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7lfc, PDBe:7lfc, PDBj:7lfc
PDBsum7lfc
PubMed35260573
UniProtO00629|IMA3_HUMAN Importin subunit alpha-3 (Gene Name=KPNA4)

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