Structure of PDB 7lcz Chain A

Receptor sequence
>7lczA (length=303) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
LEKINEVIRRAWAVPTHGHELGYSLCNSLRQSGGLDLLMKNCVKPDLQFS
SAQLLEQCLTTENRKHVVDNGLDKVVNVACVCTKNSNMEHSRVGTGILEH
LFKHSEGTCSDVIRLGGLDAVLFECRTSDLETLRHCASALANLSLYGGAE
NQEEMILRKVPMWLFPLAFHNDDNIKYYACLAIAVLVANKEIEAEVLKSG
CLDLVEPFVTSHDPSAFARSNLAHAHGQSKHWLKRLVPVLSSNREEARNL
AAFHFCMEAGIKREQGNTDIFREINAIEALKNVASCPNAIASKFAAQALR
LIG
3D structure
PDB7lcz SARM1 is a metabolic sensor activated by an increased NMN/NAD + ratio to trigger axon degeneration.
ChainA
Resolution1.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.6: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NMN A W385 E429 Q430 C431 L432 H473 A596 H597 H599 W12 E56 Q57 C58 L59 H100 A223 H224 H226
Gene Ontology
Molecular Function
GO:0003953 NAD+ nucleosidase activity
GO:0035591 signaling adaptor activity
Biological Process
GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway
GO:0048678 response to axon injury

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Molecular Function
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Biological Process
External links
PDB RCSB:7lcz, PDBe:7lcz, PDBj:7lcz
PDBsum7lcz
PubMed33657413
UniProtQ6IDD9|SARM1_DROME NAD(+) hydrolase sarm1 (Gene Name=Sarm)

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