Structure of PDB 7lcu Chain A

Receptor sequence

>7lcuA (length=470) Species: 9606 (Homo sapiens)

YQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKN
HPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNG
VCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDD
GKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYT
NSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQK
CTESHTGTSASAPLAAGIIALTLEANKDLTWRDMQHLVVQTSKPAHLNAN
DWATNGVGRKVSHSYGYGLLDAGAMVALAQDWTTVAPQRKCIIDILTEPK
DIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPM
GTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANN
YGTLTKFTLVLYGTAGENLY

3D structure

• PDB: 7lcu A highly selective, cell-permeable furin inhibitor BOS-318 rescues key features of cystic fibrosis airway disease.
• Chain: A
• Resolution: 1.24 Å

Enzymatic activity

• Enzyme Commision number: 3.4.21.75: furin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	A	D115 D162 V205 N208 V210 G212	D6 D53 V96 N99 V101 G103
BS02	CA	A	D174 D179 D181	D65 D70 D72
BS03	CA	A	T309 S311 T314 S316	T200 S202 T205 S207
BS04	CA	A	D258 D301 E331	D149 D192 E222
BS05	XTA	A	H194 M226 V231 T232 D233 E236 L240 W254 G255 D264 G265 W291 Y308	H85 M117 V122 T123 D124 E127 L131 W145 G146 D155 G156 W182 Y199

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0008236 serine-type peptidase activity

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:7lcu, PDBe:7lcu, PDBj:7lcu
• PDBsum: 7lcu
• PubMed: 35202587
• UniProt: P09958|FURIN_HUMAN Furin (Gene Name=FURIN)