Structure of PDB 7lbw Chain A

Receptor sequence

>7lbwA (length=193) Species: 9606 (Homo sapiens) [Search protein sequence]

SVLASCPKKPVSSYLRFSKEQLPIFKAQNPDAKTTELIRRIAQRWRELPD
SKKKIYQDAYRAEWQVYKEEISRFKEQLTPSQIMSLEKEIMDKHLKRKAM
TKKKELTLLGKPKRPRSAYNVYVAERFQEAKGDSPQEKLKTVKENWKNLS
DSEKELYIQHAKEDETRYHNEMKSWEEQMIEVGRKDLLRRTIK

3D structure

PDB

7lbw A minimal motif for sequence recognition by mitochondrial transcription factor A (TFAM).

Chain

Resolution

2.84 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	R157 Y162 Q179 L182 K183 K186 Y211 R232 R233 T234 K236	R114 Y119 Q136 L139 K140 K143 Y168 R189 R190 T191 K193
BS02	dna	A	K52 S55 Y57 T78 I81 A85 W88 R89 Y103 W107 R140	K9 S12 Y14 T35 I38 A42 W45 R46 Y60 W64 R97
BS03	dna	A	K51 L58 K62 T77 R140	K8 L15 K19 T34 R97
BS04	dna	A	K146 K156 R157 R159 N163 V166 A167 F170 P178	K103 K113 R114 R116 N120 V123 A124 F127 P135

External links

PDB	RCSB:7lbw, PDBe:7lbw, PDBj:7lbw
PDBsum	7lbw
PubMed	34928349
UniProt	Q00059\|TFAM_HUMAN Transcription factor A, mitochondrial (Gene Name=TFAM)

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