Structure of PDB 7l9f Chain A

Receptor sequence
>7l9fA (length=335) Species: 9606 (Homo sapiens) [Search protein sequence]
AGAARSLSRFRGCLAGALLGDCVGSFYEVDLTSVLRHVQSLTEALYYTDD
TAMARALVQSLLAKEAFDEVDMAHRFAQEYKKDPDRGYGAGVVTVFKKLL
NPKCRDVFEPARAQFNGKGSYGNGGAMRVAGISLAYSSVQDVQKFARLSA
QLTHASSLGYNGAILQALAVHLALQGESSSEHFLKQLLGHMEDLEGDAQS
VLDARELGMEERPYSSRLKKIGELLDQASVTREEVVSELGNGIAAFESVP
TAIYCFLRCMEPDPEIPSAFNSLQRTLIYSISLGGDTDTIATMAGAIAGA
YYGMDQVPESWQQSCEGYEETDILAQSLHRVFQKS
3D structure
PDB7l9f Structural and biochemical analysis of human ADP-ribosyl-acceptor hydrolase 3 reveals the basis of metal selectivity and different roles for the two magnesium ions.
ChainA
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.143: poly(ADP-ribose) glycohydrolase.
3.2.2.-
3.5.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AR6 A D77 G117 G119 V120 F143 S148 Y149 G150 N151 G152 H182 I271 D314 D49 G89 G91 V92 F115 S120 Y121 G122 N123 G124 H154 I243 D286
BS02 CA A D314 D316 T317 D286 D288 T289
BS03 CA A T76 D77 D78 D316 T48 D49 D50 D288
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004649 poly(ADP-ribose) glycohydrolase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0046872 metal ion binding
GO:0061463 O-acetyl-ADP-ribose deacetylase activity
GO:0140292 ADP-ribosylserine hydrolase activity
Biological Process
GO:0006281 DNA repair
GO:0006287 base-excision repair, gap-filling
GO:0060546 negative regulation of necroptotic process
GO:0071451 cellular response to superoxide
GO:0140290 peptidyl-serine ADP-deribosylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0016604 nuclear body
GO:0090734 site of DNA damage

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7l9f, PDBe:7l9f, PDBj:7l9f
PDBsum7l9f
PubMed33894202
UniProtQ9NX46|ADPRS_HUMAN ADP-ribosylhydrolase ARH3 (Gene Name=ADPRS)

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