Structure of PDB 7l8h Chain A

Receptor sequence
>7l8hA (length=185) Species: 42789 (enterovirus D68) [Search protein sequence]
SHMASGPGFDFAQAIMKKNTVIARTEKGEFTMLGVYDRVAVIPTHASVGE
TIYINDVETKVLDACALRDLTDTNLEITIVKLDRNQKFRDIRHFLPRYED
DYNDAVLSVHTSKFPNMYIPVGQVTNYGFLNLGGTPTHRILMYNFPTRAG
QCGGVVTTTGKVIGIHVGGNGAQGFAAMLLHSYFS
3D structure
PDB7l8h Pan-3C Protease Inhibitor Rupintrivir Binds SARS-CoV-2 Main Protease in a Unique Binding Mode.
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AG7 A H40 E71 L125 N126 L127 G128 T130 T142 A144 C147 H161 V162 G163 G164 N165 H45 E76 L130 N131 L132 G133 T135 T147 A149 C152 H166 V167 G168 G169 N170
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7l8h, PDBe:7l8h, PDBj:7l8h
PDBsum7l8h
PubMed34506130
UniProtA0A097BW12

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