Structure of PDB 7l69 Chain A

Receptor sequence

>7l69A (length=427) Species: 9606 (Homo sapiens) [Search protein sequence]

MATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAV
SYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVM
EIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGL
PQGPTVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIE
RETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKI
RSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGI
EHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKD
RNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKN
CNTSGIQTEWSPPLTMLFLCATKFSAS

3D structure

PDB

7l69 Crystal structure of human polymerase eta complexed with syn N7-benzylguanine

Chain

Resolution

1.91 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	Q38 Y39 W42 G46 I47 I48 S62 W64 K86 L89 K293 K311 P316 K317 T318 G320 S322 K323 N324 P326	Q38 Y39 W42 G46 I47 I48 S62 W64 K86 L89 K288 K306 P311 K312 T313 G315 S317 K318 N319 P321
BS02	dna	A	S113 D115 K224 S257 G259 G260 K261 L262 R377 L381 R382	S113 D115 K219 S252 G254 G255 K256 L257 R372 L376 R377

Gene Ontology

	Molecular Function
GO:0003684	damaged DNA binding

	Biological Process
GO:0006281	DNA repair

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:7l69, PDBe:7l69, PDBj:7l69
PDBsum	7l69
PubMed
UniProt	Q9Y253\|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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