Structure of PDB 7l4n Chain A

Receptor sequence

>7l4nA (length=352) Species: 3702 (Arabidopsis thaliana)

PIRLPNPMIGFGVPNEPGLITHRSLPELARGPPFFYYENVALTPKGVWET
ISRHLFEIPPEFVDSKYFCVAARKRGYIHNLPINNRFQIQPPPKYTIHDA
FPLSKRWWPEWDKRTKLNCILTRTGSAQLTNRIRVALEPYNEEPEPPKHV
QRYVIDQCKKWNLVWVGKNKAAPLEPDEMESILGFPKNHTRGGGMSRTER
FKSLGNSFQVDTVAYHLSVLKPIFPHGINVLSLFTGIGGGEVALHRLQIK
MKLVVSVEISKVNRNILKDFWEQTNQTGELIEFSDIQHLTNDTIEGLMEK
YGGFDLVIGGSPCNNLAGGNRVSRVGLEGDQSSLFFEYCRILEVVRARMR
GS

3D structure

• PDB: 7l4n Substrate deformation regulates DRM2-mediated DNA methylation in plants.
• Chain: A
• Resolution: 2.247 Å

Enzymatic activity

• Enzyme Commision number: 2.1.1.37: DNA (cytosine-5-)-methyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	R277 P318 K319 S400 A401 Q402 S470 R471 T472 G592 R595 R598	R3 P44 K45 S126 A127 Q128 S196 R197 T198 G318 R321 R324
BS02	dna	A	E312 V314 R347 K348 R349 N392 C393 L395 T396 R397 R426 G479 N480 G584 S585 P586 C587 N588 G592 G593 N594 R595	E38 V40 R73 K74 R75 N118 C119 L121 T122 R123 R152 G205 N206 G310 S311 P312 C313 N314 G318 G319 N320 R321
BS03	SAH	A	N480 S481 F482 F508 T509 G510 I511 G513 E532 I533 S558 D559 I560 G584 L608	N206 S207 F208 F234 T235 G236 I237 G239 E258 I259 S284 D285 I286 G310 L334

Gene Ontology

Molecular Function

• GO:0008168 methyltransferase activity

External links

• PDB: RCSB:7l4n, PDBe:7l4n, PDBj:7l4n
• PDBsum: 7l4n
• PubMed: 34078593
• UniProt: Q9M548|DRM2_ARATH DNA (cytosine-5)-methyltransferase DRM2 (Gene Name=DRM2)