Structure of PDB 7l4m Chain A

Receptor sequence

>7l4mA (length=350) Species: 3702 (Arabidopsis thaliana) [Search protein sequence]

PIRLPNPMIGFGVPNEPGLITHRSLPELARGPPFFYYENVALTPKGVWET
ISRHLFEIPPEFVDSKYFCVAARKRGYIHNLPINNRFQIQPPPKYTIHDA
FPLSKRWWPEWDKRTKLNCILTCTGSAQLTNRIRVALEPYNEEPEPPKHV
QRYVIDQCKKWNLVWVGKNKAAPLEPDEMESILGFPKNHTRGGGMSRTER
FKSLGNSFQVDTVAYHLSVLKPIFPHGINVLSLFTGIGGGEVALHRLQIK
MKLVVSVEISKVNRNILKDFWEQTNQTGELIEFSDIQHLTNDTIEGLMEK
YGGFDLVIGGSPCNNLAGGNRVSRVGLEGDQSSLFFEYCRILEVVRARMR

3D structure

PDB

7l4m Substrate deformation regulates DRM2-mediated DNA methylation in plants.

Chain

Resolution

2.805 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

2.1.1.37: DNA (cytosine-5-)-methyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	S400 R406 S470 R471 T472 G592 R595	S126 R132 S196 R197 T198 G318 R321
BS02	dna	A	E312 V314 L316 R347 R349 L395 T396 C397 R426 G479 N480 S481 S585 P586 C587 N588 G592 G593 R595 V596	E38 V40 L42 R73 R75 L121 T122 C123 R152 G205 N206 S207 S311 P312 C313 N314 G318 G319 R321 V322
BS03	SAH	A	N480 S481 F482 F508 T509 E532 I533 I560 L608	N206 S207 F208 F234 T235 E258 I259 I286 L334

Gene Ontology

	Molecular Function
GO:0008168	methyltransferase activity

View graph for
Molecular Function

External links

PDB	RCSB:7l4m, PDBe:7l4m, PDBj:7l4m
PDBsum	7l4m
PubMed	34078593
UniProt	Q9M548\|DRM2_ARATH DNA (cytosine-5)-methyltransferase DRM2 (Gene Name=DRM2)

[Back to BioLiP]