Structure of PDB 7l4h Chain A

Receptor sequence

>7l4hA (length=352) Species: 3702 (Arabidopsis thaliana)

PIRLPNPMIGFGVPNEPGLITHRSLPELARGPPFFYYENVALTPKGVWET
ISRHLFEIPPEFVDSKYFCVAARKRGYIHNLPINNRFQIQPPPKYTIHDA
FPLSKRWWPEWDKRTKLNCILTCTGSAQLTNRIRVALEPYNEEPEPPKHV
QRYVIDQCKKWNLVWVGKNKAAPLEPDEMESILGFPKNHTRGGGMSRTER
FKSLGNSFQVDTVAYHLSVLKPIFPHGINVLSLFTGIGGGEVALHRLQIK
MKLVVSVEISKVNRNILKDFWEQTNQTGELIEFSDIQHLTNDTIEGLMEK
YGGFDLVIGGSPCNNLAGGNRVSRVGLEGDQSSLFFEYCRILEVVRARMR
GS

3D structure

• PDB: 7l4h Substrate deformation regulates DRM2-mediated DNA methylation in plants.
• Chain: A
• Resolution: 2.56 Å

Enzymatic activity

• Enzyme Commision number: 2.1.1.37: DNA (cytosine-5-)-methyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	K319 S400 A401 Q402 S470 R471 T472 G592 R595 R598	K45 S126 A127 Q128 S196 R197 T198 G318 R321 R324
BS02	dna	A	E312 V314 K348 R349 N392 C393 L395 T396 C397 R426 G479 N480 S585 C587 N588 A591 G592 G593 N594 V596	E38 V40 K74 R75 N118 C119 L121 T122 C123 R152 G205 N206 S311 C313 N314 A317 G318 G319 N320 V322
BS03	SAH	A	N480 S481 F482 F508 T509 G510 I511 G513 E532 I533 D559 I560 G584 L608	N206 S207 F208 F234 T235 G236 I237 G239 E258 I259 D285 I286 G310 L334

Gene Ontology

Molecular Function

• GO:0008168 methyltransferase activity

External links

• PDB: RCSB:7l4h, PDBe:7l4h, PDBj:7l4h
• PDBsum: 7l4h
• PubMed: 34078593
• UniProt: Q9M548|DRM2_ARATH DNA (cytosine-5)-methyltransferase DRM2 (Gene Name=DRM2)