Structure of PDB 7l4c Chain A

Receptor sequence

>7l4cA (length=353) Species: 3702 (Arabidopsis thaliana)

EPIRLPNPMIGFGVPNEPGLITHRSLPELARGPPFFYYENVALTPKGVWE
TISRHLFEIPPEFVDSKYFCVAARKRGYIHNLPINNRFQIQPPPKYTIHD
AFPLSKRWWPEWDKRTKLNCILTCTGSAQLTNRIRVALEPYNEEPEPPKH
VQRYVIDQCKKWNLVWVGKNKAAPLEPDEMESILGFPKNHTRGGGMSRTE
RFKSLGNSFQVDTVAYHLSVLKPIFPHGINVLSLFTGIGGGEVALHRLQI
KMKLVVSVEISKVNRNILKDFWEQTNQTGELIEFSDIQHLTNDTIEGLME
KYGGFDLVIGGSPCNNLAGGNRVSRVGLEGDQSSLFFEYCRILEVVRARM
RGS

3D structure

• PDB: 7l4c Substrate deformation regulates DRM2-mediated DNA methylation in plants.
• Chain: A
• Resolution: 2.11 Å

Enzymatic activity

• Enzyme Commision number: 2.1.1.37: DNA (cytosine-5-)-methyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	L278 P318 K319 S400 A401 Q402 R406 S470 R471 T472 G592 N594 R595 R598	L5 P45 K46 S127 A128 Q129 R133 S197 R198 T199 G319 N321 R322 R325
BS02	dna	A	E312 V314 K348 R349 N392 C393 L395 T396 C397 G479 N480 G584 S585 P586 C587 N588 G592 G593 N594 R595 V596	E39 V41 K75 R76 N119 C120 L122 T123 C124 G206 N207 G311 S312 P313 C314 N315 G319 G320 N321 R322 V323
BS03	SAH	A	N480 S481 F482 F508 T509 G510 I511 G513 E532 I533 D559 I560 G584 L608	N207 S208 F209 F235 T236 G237 I238 G240 E259 I260 D286 I287 G311 L335

Gene Ontology

Molecular Function

• GO:0008168 methyltransferase activity

External links

• PDB: RCSB:7l4c, PDBe:7l4c, PDBj:7l4c
• PDBsum: 7l4c
• PubMed: 34078593
• UniProt: Q9M548|DRM2_ARATH DNA (cytosine-5)-methyltransferase DRM2 (Gene Name=DRM2)