Structure of PDB 7l49 Chain A

Receptor sequence

>7l49A (length=522) Species: 32644 (unidentified) [Search protein sequence]

NTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKH
LKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFR
QLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSDVCYTRAAELF
KNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYT
GFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLL
LSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWM
LNLSIDVPKIDKGVDPSIIGGIDVGVKSPLVCAINNAFSRYSISDNDLFH
FNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERW
ACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIE
FKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKC
NFKENADYNAALNISNPKLKST

3D structure

PDB

7l49 Structural basis for substrate recognition and cleavage by the dimerization-dependent CRISPR-Cas12f nuclease.

Chain

Resolution

3.1 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	T7 K167 S168 R171 Q197 Y202 S286 S307 R362 L382 T389 R396 E425 G441 P444 Y445 A446 E447	T4 K164 S165 R168 Q194 Y199 S283 S304 R359 L379 T386 R393 E422 G438 P441 Y442 A443 E444
BS02	dna	A	I131 N133 S136 H139 S142 Y146 A156 R163 K176 K179 K196 Y202 Q242 V243 Q244	I128 N130 S133 H136 S139 Y143 A153 R160 K173 K176 K193 Y199 Q239 V240 Q241
BS03	rna	A	T7 K8 T9 R13 V15 R16 K31 R66 N67 C72 K73 K76 D79 Y82 F94 W95 S99 Y113 N169 G181 P183 P191 D213 S255 T256 Q257 R258 R259 R261 N262 K263 T271 E272 E289 K291 K295 K299 S300 N305 R363 L365 L366 K367 N369 R370 K372 R373 A374 G375 H376 G377 A378 N380 K381 R394 F395 K398 E401 C405 N436 I437 F454 K455	T4 K5 T6 R10 V12 R13 K28 R63 N64 C69 K70 K73 D76 Y79 F91 W92 S96 Y110 N166 G178 P180 P188 D210 S252 T253 Q254 R255 R256 R258 N259 K260 T268 E269 E286 K288 K292 K296 S297 N302 R360 L362 L363 K364 N366 R367 K369 R370 A371 G372 H373 G374 A375 N377 K378 R391 F392 K395 E398 C402 N433 I434 F451 K452
BS04	dna	A	V329 K330 M427 K430 Y434 F435 W443 P468 N469 N470 S472 F487 R490 K491 F495	V326 K327 M424 K427 Y431 F432 W440 P465 N466 N467 S469 F484 R487 K488 F492
BS05	ZN	A	H53 C69 C72	H50 C66 C69

External links

PDB	RCSB:7l49, PDBe:7l49, PDBj:7l49
PDBsum	7l49
PubMed	33764415

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