Structure of PDB 7l48 Chain A

Receptor sequence

>7l48A (length=522) Species: 32644 (unidentified) [Search protein sequence]

NTITKTLKLRIVRPYNSAEVEKIVADEKNNREKIALEKNKDKVKEACSKH
LKVAAYCTTQVERNACLFCKARKLDDKFYQKLRGQFPDAVFWQEISEIFR
QLQKQAAEIYNQSLIELYYEIFIKGKGIANASSVEHYLSDVCYTRAAELF
KNAAIASGLRSKIKSNFRLKELKNMKSGLPTTKSDNFPIPLVKQKGGQYT
GFEISNHNSDFIIKIPFGRWQVKKEIDKYRPWEKFDFEQVQKSPKPISLL
LSTQRRKRNKGWSKDEGTEAEIKKVMNGDYQTSYIEVKRGSKICEKSAWM
LNLSIDVPKIDKGVDPSIIGGIDVGVKSPLVCAINNAFSRYSISDNDLFH
FNKKMFARRRILLKKNRHKRAGHGAKNKLKPITILTEKSERFRKKLIERW
ACEIADFFIKNKVGTVQMENLESMKRKEDSYFNIRLRGFWPYAEMQNKIE
FKLKQYGIEIRKVAPNNTSKTCSKCGHLNNYFNFEYRKKNKFPHFKCEKC
NFKENADYNAALNISNPKLKST

3D structure

PDB

7l48 Structural basis for substrate recognition and cleavage by the dimerization-dependent CRISPR-Cas12f nuclease.

Chain

Resolution

3.9 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	A	T7 K8 T9 R13 V15 R16 K31 R66 N67 C72 K73 K76 D79 Y82 F94 W95 S99 R171 P183 P191 D213 S255 T256 Q257 R258 R259 R261 K263 T271 E272 E298 K299 R361 N369 K372 R373 A374 G375 H376 G377 A378 K379 N380 K381 R394 F395 K398 E401 C405 K451 F454 K492	T4 K5 T6 R10 V12 R13 K28 R63 N64 C69 K70 K73 D76 Y79 F91 W92 S96 R168 P180 P188 D210 S252 T253 Q254 R255 R256 R258 K260 T268 E269 E295 K296 R358 N366 K369 R370 A371 G372 H373 G374 A375 K376 N377 K378 R391 F392 K395 E398 C402 K448 F451 K489
BS02	ZN	A	C475 N482 C500	C472 N479 C497
BS03	ZN	A	C50 H53 C69	C47 H50 C66

External links

PDB	RCSB:7l48, PDBe:7l48, PDBj:7l48
PDBsum	7l48
PubMed	33764415

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