Structure of PDB 7l34 Chain A

Receptor sequence

>7l34A (length=637) Species: 9606 (Homo sapiens) [Search protein sequence]

SNDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMV
ETLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLELGVGDGVLLKAVA
QATGRQLESVRAEAAEKGDVGLVAENSRLMLPPPPLTASGVFSKFRDIAR
LTGSASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAAL
SQAVSLTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEVPDL
DRIIPVLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEEAAF
TCEYKYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPDIISRIPKIKLPSV
TSFILDTEAVAWDREKKQIQPFQVLTTLKRKEVDASEIQVQVCLYAFDLI
YLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQ
SVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIG
AYLGRGKRAGRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQSLK
ALVLPSPRPYVRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAARGLVD
SDKGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQ

3D structure

PDB

7l34 LIG1 syndrome mutations remodel a cooperative network of ligand binding interactions to compromise ligation efficiency.

Chain

Resolution

1.901 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

6.5.1.1: DNA ligase (ATP).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	E346 L347 G348 G350 G571 Q572 S588 R589 E592 F635 F872	E87 L88 G89 G91 G308 Q309 S325 R326 E329 F372 F609
BS02	dna	A	S303 R549 K744 K746 Y749 T798 G799 F800 S801 D802 F872 R874	S44 R286 K481 K483 Y486 T535 G536 F537 S538 D539 F609 R611
BS03	dna	A	R305 T415 G416 A418 T420 R451 G453 A455 Q457 S458 R557 Q636 T639 K642 R738 G767 R768 G769 K770 G776 K795 G797 S850 L851 S852 P853 Y855 S869 L870 F872	R46 T152 G153 A155 T157 R188 G190 A192 Q194 S195 R294 Q373 T376 K379 R475 G504 R505 G506 K507 G513 K532 G534 S587 L588 S589 P590 Y592 S606 L607 F609
BS04	AMP	A	K568 Y569 R573 R589 E621 F660 M723 K725 W742 K744	K305 Y306 R310 R326 E358 F397 M460 K462 W479 K481

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003909	DNA ligase activity
GO:0003910	DNA ligase (ATP) activity
GO:0005524	ATP binding

	Biological Process
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0071897	DNA biosynthetic process

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:7l34, PDBe:7l34, PDBj:7l34
PDBsum	7l34
PubMed	33444456
UniProt	P18858\|DNLI1_HUMAN DNA ligase 1 (Gene Name=LIG1)

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