Structure of PDB 7l28 Chain A

Receptor sequence
>7l28A (length=363) Species: 9606 (Homo sapiens) [Search protein sequence]
KPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRL
FEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLT
TQPIPGLSTVSYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYD
HPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINL
DHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRL
LVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPF
MDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVRKIYCQITQHLL
QNHKMWKKVIEEE
3D structure
PDB7l28 Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XKG A F972 L1000 S1003 F1004 F283 L311 S314 F315 BindingDB: IC50=0.3nM
BS02 MN A H756 H836 D837 D950 H88 H147 D148 D261
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:7l28, PDBe:7l28, PDBj:7l28
PDBsum7l28
PubMed34272366
UniProtQ14432|PDE3A_HUMAN cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Gene Name=PDE3A)

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