Structure of PDB 7l1f Chain A

Receptor sequence
>7l1fA (length=832) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence]
YRAFDIYNDKVAGFAKFLKETIYNLLKDCPAVAKHDLTKYTMADLVYALR
HFDEGNCDTLKEILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERV
RQALLKTVQFCDAMRNAGIVGVLTLDNQDLNGNWYDFGDFIQTTPGSGVP
VVDSYYSLLMPILTLTRALTAESHVDTDLTKPYIKWDLLKYDFTEERLKL
FDRYFKYWDQTYHPNCVNCLDDRCILHCANFNVLFSTVFPPTSFGPLVRK
IFVDGVPFVVSTGYHFRELGVVHNQDVNLHSSRLSFKELLVYAADPAMHA
ASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEG
SSVELKHFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKYFDC
YDGGCINANQVIVNNLDKSAGFPFNKWGKARLYYDSMSYEDQDALFAYTK
RNVIPTITQMNLKYAISAKNRARTVAGVSICSTMTNRQFHQKLLKSIAAT
RGATVVIGTSKFYGGWHNMLKTVYSDVENPHLMGWDYPKCDRAMPNMLRI
MASLVLARKHTTCCSLSHRFYRLANECAQVLSEMVMCGGSLYVKPGGTSS
GDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLY
RNRDVDTDFVNEFYAYLRKHFSMMILSDDAVVCFNSTYASQGLVASIKNF
KSVLYYQNNVFMSEAKCWTETDLTKGPHEFCSQHTMLVKQGDDYVYLPYP
DPSRILGAGCFVDDIVKTDGTLMIERFVSLAIDAYPLTKHPNQEYADVFH
LYLQYIRKLHDELNTSRYWEPEFYEAMYTPHT
3D structure
PDB7l1f Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication.
ChainA
Resolution3.89 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A R555 T687 A688 N691 L758 S759 D760 C813 R836 K849 R858 R473 T605 A606 N609 L676 S677 D678 C731 R754 K767 R776
BS02 rna A N496 K500 S501 N543 G590 S592 Y595 G683 A685 Y689 N414 K418 S419 N461 G508 S510 Y513 G601 A603 Y607
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005524 ATP binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039694 viral RNA genome replication

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7l1f, PDBe:7l1f, PDBj:7l1f
PDBsum7l1f
PubMed33631104
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

[Back to BioLiP]