Structure of PDB 7kyc Chain A

Receptor sequence
>7kycA (length=1178) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
ELRTVYYNMPLPKDMIDEEGNPIMQYPRNKIRTTKYTPLTFLPKNILFQF
HNFANVYFLVLIILGAFQIFGVTNPGLSAVPLVVIVIITAIKDAIEDSRR
TVLDLEVNNTKTHILEGVENENVSNIVDRSLPPRTDCKFAKNYWKGVKVG
DIVRIHNNDEIPADIILLSTSDTDGACYVETKNLDGETNLKVRQSLKCTN
TIRTSKDIARTKFWIESEGPHSNLYTYQGNMKWRNLADGEIRNEPITINN
VLLRGCTLRNTKWAMGVVMFTGGDTKIMLNSGITPTKKSRISRELNFSVV
INFVLLFILCFVSGIANGVYYDKKGRSRFSYEFGTIAGSAATNGFVSFWV
AVILYQSLVPISLYISVEIIKTAQAAFIYGDVLLYNAKLDYPCTPKSWNI
SDDLGQVEYIFSDKTGTLTQNVMEFKKCTINGVSYGRAYTEALAGLRKRQ
GIDVETEGRREKAEIAKDRDTMIDELRALSGNSQFYPEEVTFVSKEFVRD
LKGASGEVQQRCCEHFMLALALCHSVLVEANPDNPKKLDLKAQSPDEAAL
VATARDVGFSFVGKTKKGLIIEMQGIQKEFEILNILEFNSSRKRMSCIVK
IPGEPRALLICKGADSIIYSRLSRQSNSEAILEKTALHLEQYATEGLRTL
CIAQRELSWSEYEKWNEKYDIAAASLANREDELEVVADSIERELILLGGT
AIEDRLQDGVPDCIELLAEAGIKLWVLTGDKVETAINIGFSCNLLNNEME
LLVIKTTGDDVKEFGSEPSEIVDALLSKYLKEYFNLTGSEEEIFEAKKDH
EFPKGNYAIVIDGDALKLALYGEDIRRKFLLLCKNCRAVLCCRVSPSQKA
AVVKLVKDSLDVMTLAIGDGSNDVAMIQSADVGIGIAGEEGRQAVMCSDY
AIGQFRYLARLVLVHGRWSYKRLAEMIPEFFYKNMIFALALFWYGIYNDF
DGSYLYEYTYMMFYNLAFTSLPVIFLGILDQDVNDTISLVVPQLYRVGIL
RKEWNQRKFLWYMLDGLYQSIICFFFPYLVYHKNMIVTSNGLGLDHRYFV
GVYVTTIAVISCNTYVLLHQYRWDWFSGLFIALSCLVVFAWTGIWSSAIA
SREFFKAAARIYGAPSFWAVFFVAVLFCLLPRFTYDSFQKFFYPTDVEIV
REMWQHGHFDHYPPGYDPTDPNRPKVTK
3D structure
PDB7kyc Transport mechanism of P4 ATPase phosphatidylcholine flippases.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.6.2.1: P-type phospholipid transporter.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BEF A G440 D667 T669 T989 G990 K1110 G186 D413 T415 T728 G729 K849
BS02 MG A D667 T669 D1130 D413 T415 D869
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0090554 phosphatidylcholine floppase activity
GO:0090555 phosphatidylethanolamine flippase activity
GO:0090556 phosphatidylserine floppase activity
GO:0140326 ATPase-coupled intramembrane lipid transporter activity
GO:0140345 phosphatidylcholine flippase activity
GO:0140346 phosphatidylserine flippase activity
GO:0140351 glycosylceramide flippase activity
Biological Process
GO:0006869 lipid transport
GO:0006886 intracellular protein transport
GO:0006897 endocytosis
GO:0007163 establishment or maintenance of cell polarity
GO:0015914 phospholipid transport
GO:0045332 phospholipid translocation
GO:0099040 ceramide translocation
GO:0140331 aminophospholipid translocation
Cellular Component
GO:0005739 mitochondrion
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005933 cellular bud
GO:0005935 cellular bud neck
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0030428 cell septum
GO:0070867 mating projection tip membrane
GO:0071944 cell periphery
GO:1990531 phospholipid-translocating ATPase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7kyc, PDBe:7kyc, PDBj:7kyc
PDBsum7kyc
PubMed33320091
UniProtP32660|ATC5_YEAST Phospholipid-transporting ATPase DNF1 (Gene Name=DNF1)

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