Structure of PDB 7kya Chain A

Receptor sequence
>7kyaA (length=1174) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
NRSDELRTVYYNLPLPEDMLDEDGLPLAVYPRNKIRTTKYTPLTFFPKNI
LFQFHNFANIYFLILLILGAFQIFGVTNPGFASVPLIVIVIITAIKDGIE
DSRRTVLDLEVNNTRTHILSGVKNENVANLVDRTLQPNPECRFAKDYWKN
VKVGDIVRVHNNDEIPADMILLSTSDVDGACYVETKNLDGETNLKVRQSL
KCSKIIKSSRDITRTKFWVESEGPHANLYSYQGNFKWQDTQNGNIRNEPV
NINNLLLRGCTLRNTKWAMGMVIFTGDDTKIMINAGVTPTKKSRISRELN
FSVILNFVLLFILCFTAGIVNGVYYKQKPRSRDYFEFASTNGFVSFWVAV
ILYQSLVPISLYISVEIIKTAQAIFIYTDVLLYNAKLDYPCTPKSWNISD
DLGQIEYIFSDKTGTLTQNVMEFKKCTINGVSYGRAYTEALAGLRKRQGV
DVESEGRREKEEIAKDRETMIDELRSMSDNTQFCPEDLTFVSKEIVEDLK
GSSGDHQQKCCEHFLLALALCHSVLVEPNKDDPKKLDIKAQSPDESALVS
TARQLGYSFVGSSKSGLIVEIQGVQKEFQVLNVLEFNSSRKRMSCIIKIP
GEPKALLICKGADSVIYSRLDRTQNDATLLEKTALHLEEYATEGLRTLCL
AQRELTWSEYERWVKTYDVAAASVTNREEELDKVTDVIERELILLGGTAI
EDRLQDGVPDSIALLAEAGIKLWVLTGDKVETAINIGFSCNVLNNDMELL
VVKASGEDVEEFGSDPIQVVNNLVTKYLREKFGMSGSEEELKEAKREHGL
PQGNFAVIIDGDALKVALNGEEMRRKFLLLCKNCKAVLCCRVSPAQKAAV
VKLVKKTLDVMTLAIGDGSNDVAMIQSADVGVGIAGEEGRQAVMCSDYAI
GQFRYVTRLVLVHGKWCYKRLAEMIPQFFYKNVIFTLSLFWYGIYNNFDG
SYLFEYTYLTFYNLAFTSVPVILLAVLDQDVSDTVSMLVPQLYRVGILRK
EWNQTKFLWYMLDGVYQSVICFFFPYLAYHKNMVVTENGLGLDHRYFVGV
FVTAIAVTSCNFYVFMEQYRWDWFCGLFICLSLAVFYGWTGIWTSSSSSN
EFYKGAARVFAQPAYWAVLFVGVLFCLLPRFTIDCIRKIFYPKDIEIVRE
MWLRGDFDLYPQGYDPTDPSRPRI
3D structure
PDB7kya Transport mechanism of P4 ATPase phosphatidylcholine flippases.
ChainA
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.6.2.1: P-type phospholipid transporter.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR A T611 W1247 T316 W941
BS02 MG A T714 D1173 T413 D867
BS03 BEF A D484 G485 D712 K713 T714 G1033 N1176 D189 G190 D411 K412 T413 G727 N870
BS04 CLR A F610 A639 S640 F647 F315 A338 S339 F346
BS05 CLR A I1439 I1442 Y1447 I1133 I1136 Y1141
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015247 aminophospholipid flippase activity
GO:0016887 ATP hydrolysis activity
GO:0046872 metal ion binding
GO:0090554 phosphatidylcholine floppase activity
GO:0090555 phosphatidylethanolamine flippase activity
GO:0090556 phosphatidylserine floppase activity
GO:0140326 ATPase-coupled intramembrane lipid transporter activity
GO:0140346 phosphatidylserine flippase activity
GO:0140351 glycosylceramide flippase activity
Biological Process
GO:0006869 lipid transport
GO:0006897 endocytosis
GO:0007163 establishment or maintenance of cell polarity
GO:0015031 protein transport
GO:0015914 phospholipid transport
GO:0045332 phospholipid translocation
GO:0099040 ceramide translocation
GO:0140331 aminophospholipid translocation
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005935 cellular bud neck
GO:0016020 membrane
GO:0070867 mating projection tip membrane
GO:0071944 cell periphery
GO:1990531 phospholipid-translocating ATPase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7kya, PDBe:7kya, PDBj:7kya
PDBsum7kya
PubMed33320091
UniProtQ12675|ATC4_YEAST Phospholipid-transporting ATPase DNF2 (Gene Name=DNF2)

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