Structure of PDB 7ky8 Chain A

Receptor sequence
>7ky8A (length=910) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
GFASVPLIVIVIITAIKDGIEDSRTKKSRISRELNFSVILNFVLLFILCF
TAGIVNGVYYKQKPRSRDYFEFGTIGGSASTNGFVSFWVAVILYQSLVPI
SLYISVEIIKTAQAIFIYTDVLLYNAKLDYPCTPKSWNISDDLGQIEYIF
SDKTGTLTQNVMEFKKCTINGVSYGRAYTEALAGLRKRQGVDVESEGRRE
KEEIAKDRETMIDELRSMSDNTQFCPEDLTFVSKEIVEDLKGSSGDHQQK
CCEHFLLALALCHSVLVEPNKDDPKKLDIKAQSPDESALVSTARQLGYSF
VGSSKSGLIVEIQGVQKEFQVLNVLEFNSSRKRMSCIIKIPGEPKALLIC
KGADSVIYSRLDRTQNDATLLEKTALHLEEYATEGLRTLCLAQRELTWSE
YERWVKTYDVAAASVTNREEELDKVTDVIERELILLGGTAIEDRLQDGVP
DSIALLAEAGIKLWVLTGDKVETAINIGFSCNVLNNDMELLVVKASGEDV
EEFGSDPIQVVNNLVTKYLREKFGMSGSEEELKEAKREHGLPQGNFAVII
DGDALKVALNGEEMRRKFLLLCKNCKAVLCCRVSPAQKAAVVKLVKKTLD
VMTLAIGDGSNDVAMIQSADVGVGIAGEEGRQAVMCSDYAIGQFRYVTRL
VLVHGKWCYKRLAEMIPQFFYKNVIFTLSLFWYGIYNNFDGSYLFEYTYL
TFYNLAFTSVPVILLAVLDQDVSDTVSMLVPQLYRVGILRKEWNQTKFLW
YMLDGVYQSVICFFFPYLAYHKNMVVTENGLGLDHRYFVGVFVTAIAVTS
CNFYVFMEQYRWDWFCGLFICLSLAVFYGWTGIWTSSSSSNEFYKGAARV
FAQPAYWAVLFVGVLFCLLPRFTIDCIRKIFYPKDIEIVREMWLRGDFDL
YPQGYDPTDP
3D structure
PDB7ky8 Transport mechanism of P4 ATPase phosphatidylcholine flippases.
ChainA
Resolution3.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.6.2.1: P-type phospholipid transporter.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR A L608 V615 F1246 L48 V55 F681
BS02 CLR A W1315 D1319 Y1322 R1436 I1439 R1443 W750 D754 Y757 R871 I874 R878
BS03 MG A T714 D1173 T154 D608
BS04 ACP A T714 D845 F887 S889 K892 R893 M894 K916 R952 G1033 T154 D285 F327 S329 K332 R333 M334 K351 R387 G468
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015247 aminophospholipid flippase activity
GO:0016887 ATP hydrolysis activity
GO:0046872 metal ion binding
GO:0090554 phosphatidylcholine floppase activity
GO:0090555 phosphatidylethanolamine flippase activity
GO:0090556 phosphatidylserine floppase activity
GO:0140326 ATPase-coupled intramembrane lipid transporter activity
GO:0140346 phosphatidylserine flippase activity
GO:0140351 glycosylceramide flippase activity
Biological Process
GO:0006869 lipid transport
GO:0006897 endocytosis
GO:0007163 establishment or maintenance of cell polarity
GO:0015031 protein transport
GO:0015914 phospholipid transport
GO:0045332 phospholipid translocation
GO:0099040 ceramide translocation
GO:0140331 aminophospholipid translocation
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005935 cellular bud neck
GO:0016020 membrane
GO:0070867 mating projection tip membrane
GO:0071944 cell periphery
GO:1990531 phospholipid-translocating ATPase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ky8, PDBe:7ky8, PDBj:7ky8
PDBsum7ky8
PubMed33320091
UniProtQ12675|ATC4_YEAST Phospholipid-transporting ATPase DNF2 (Gene Name=DNF2)

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