Structure of PDB 7ky7 Chain A

Receptor sequence
>7ky7A (length=884) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
GFASVPLIVIVIITAIKDGIEDSRTKKSRISRELNFSVILNFVLLFILCF
TAGIVNGVYYKQKPRSRDYFEFSTNGFVSFWVAVILYQSLVPISLYISVE
IIKTAQAIFIYTDVLLYNAKLDYPCTPKSWNISDDLGQIEYIFSDKTGTL
TQNVMEFKKCTINGVSYGRAYTEALAGLRKRQGVDVESEGRREKEEIAKD
RETMIDELRSMSDNTQFCPEDLTFVSKEIVEDLKGSSGDHQQKCCEHFLL
ALALCHSVLVEPNKDDPKKLDIKAQSPDESALVSTARQLGYSFVGSSKSG
LIVEIQGVQKEFQVLNVLEFNSSRKRMSCIIKIPKGADSVIYSRLDRNDA
TLLEKTALHLEEYATEGLRTLCLAQREEYERWVKTYDVAAASVTNREEEL
DKVTDVIERELILLGGTAIEDRLQDGVPDSIALLAEAGIKLWVLTGDKVE
TAINIGFSCNVLNNDMELLVVKASGEDVSDPIQVVNNLVTKYLREKFGMS
GSEEELKEAKREHGLPQGNFAVIIDGDALKVALNGEEMRRKFLLLCKNCK
AVLCCRVSPAQKAAVVKLVKKTLDVMTLAIGDGSNDVAMIQSADVGVGIA
GEEGRQAVMCSDYAIGQFRYVTRLVLVHGKWCYKRLAEMIPQFFYKNVIF
TLSLFWYGIYNNFDGSYLFEYTYLTFYNLAFTSVPVILLAVLDQDVSDTV
SMLVPQLYRVGILRKEWNQTKFLWYMLDGVYQSVICFFFPYLAYHKNMVV
TENGLGLDHRYFVGVFVTAIAVTSCNFYVFMEQYRWDWFCGLFICLSLAV
FYGWTGIWTSSSSSNEFYKGAARVFAQPAYWAVLFVGVLFCLLPRFTIDC
IRKIFYPKDIEIVREMWLRGDFDLYPQGYDPTDP
3D structure
PDB7ky7 Transport mechanism of P4 ATPase phosphatidylcholine flippases.
ChainA
Resolution3.08 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 7.6.2.1: P-type phospholipid transporter.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A T714 D1173 T147 D582
BS02 CLR A T611 F1246 T51 F655
BS03 CLR A V1325 F1329 V734 F738
BS04 CLR A W1315 L1318 D1319 P1435 R1436 I1439 W724 L727 D728 P844 R845 I848
BS05 CLR A P1419 F1426 P828 F835
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015247 aminophospholipid flippase activity
GO:0016887 ATP hydrolysis activity
GO:0046872 metal ion binding
GO:0090554 phosphatidylcholine floppase activity
GO:0090555 phosphatidylethanolamine flippase activity
GO:0090556 phosphatidylserine floppase activity
GO:0140326 ATPase-coupled intramembrane lipid transporter activity
GO:0140346 phosphatidylserine flippase activity
GO:0140351 glycosylceramide flippase activity
Biological Process
GO:0006869 lipid transport
GO:0006897 endocytosis
GO:0007163 establishment or maintenance of cell polarity
GO:0015031 protein transport
GO:0015914 phospholipid transport
GO:0045332 phospholipid translocation
GO:0099040 ceramide translocation
GO:0140331 aminophospholipid translocation
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005935 cellular bud neck
GO:0016020 membrane
GO:0070867 mating projection tip membrane
GO:0071944 cell periphery
GO:1990531 phospholipid-translocating ATPase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7ky7, PDBe:7ky7, PDBj:7ky7
PDBsum7ky7
PubMed33320091
UniProtQ12675|ATC4_YEAST Phospholipid-transporting ATPase DNF2 (Gene Name=DNF2)

[Back to BioLiP]