Structure of PDB 7kxs Chain A

Receptor sequence
>7kxsA (length=348) Species: 10090 (Mus musculus) [Search protein sequence]
PDKLKKVLDKLRLDPKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLF
IYEKVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKRIPRGNPLS
HFLEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIR
NPEEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVP
KQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRMECLMLMKYLLEQ
LKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFL
ECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFD
3D structure
PDB7kxs Computational design of constitutively active cGAS.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H378 C385 C392 H221 C228 C235
External links
PDB RCSB:7kxs, PDBe:7kxs, PDBj:7kxs
PDBsum7kxs
PubMed36593311
UniProtQ8C6L5|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)

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