Structure of PDB 7kxq Chain A

Receptor sequence
>7kxqA (length=270) Species: 9606 (Homo sapiens) [Search protein sequence]
LGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSE
DEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREM
RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSD
FGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWE
IYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKAD
ERPTFKILLSNILDVMDEES
3D structure
PDB7kxq Discovery of potent and selective reversible Bruton's tyrosine kinase inhibitors.
ChainA
Resolution1.38 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D521 R525 N526 D539
Catalytic site (residue number reindexed from 1) D132 R136 N137 D150
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 X9Y A L408 G409 T410 G411 F413 V416 A428 K430 Y476 M477 A478 G480 N526 L528 D539 L542 L19 G20 T21 G22 F24 V27 A39 K41 Y87 M88 A89 G91 N137 L139 D150 L153
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7kxq, PDBe:7kxq, PDBj:7kxq
PDBsum7kxq
PubMed33932711
UniProtQ06187|BTK_HUMAN Tyrosine-protein kinase BTK (Gene Name=BTK)

[Back to BioLiP]