Structure of PDB 7kx9 Chain A

Receptor sequence

>7kx9A (length=734) Species: 31330 (Ephydatia fluviatilis)

SQRGSSGQPVPVSANYLPLKGNMDGVFKYAVGFNPPVEDIRSRSQLLNEH
KELIGLTRVFDGSTLYVPKRICEQRLDLMSTRQTDGASIKVTISLVDSVK
NRDVVQLMNVIFKRILRSLKLQRIGRDYYDANSPLEVPQHKMQLWPGYVT
AINRHEGGLMLVLDVSHRVMKTDTALDFLYELYHFKQLVGSVVLTRYNNR
TYEIDDIAWDKNPRCAFQDHAGSQITFVDYYKRAYDLDITDLEQPLLIHR
PKEMVCLVPELCAMTGLTDAARSDFKVMKDLAVHTRVPPEKRAESFRKFI
QRLNTTKEASELLHSWGLVLDSRMLDMQGRRLPPEKILFKHSSIVANMEA
DWSRECLKEHVISAVSLLDWAVLFVRKDQGKATDFVNMLSKVCPPIGMEV
HEPKMVEVVNDRTESYLRALRELIAPRLQMVVIVFPTSRDDRYSAVKKLC
CIESPIPSQVLIARTITQQQKLRSVAQKVALQMNAKLGGELWAVEIPLKS
CMVVGIDVYHDKSYGNKSIAGFVASTNPSFTRWYSRTAMQEQSQELIHEL
KLCMQAALKKYNEMNQSLPERIIVFRDGVGEGREEYVSEFEVPQFNSCFS
IFGENYCPKLAVVVVQKRITTRIFGRSGHSYDNPPPGVIVDHTITKSYDF
YLVSQHVRQGTVSPTYYRVIYDKSGLKPDHLQRLTYKLTHMYYNWPGTIR
TPAPCNYAHKLAFLVGKSLHRDPAHELSDRLFFL

3D structure

• PDB: 7kx9 Structural basis for piRNA targeting.
• Chain: A
• Resolution: 3.5 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	Y435 Y440 F455 H458 F465 Y468 Y473 T538 R539 S691 Y696 K700 Q712 V713 I715 T718 Q735 T914 Y945 R953 L987	Y197 Y202 F217 H220 F227 Y230 Y235 T285 R286 S438 Y443 K447 Q459 V460 I462 T465 Q482 T661 Y692 R700 L734
BS02	rna	A	R351 G353 R354 K490 Q723 K724 S727 K731 H763 R871 F966	R123 G125 R126 K252 Q470 K471 S474 K478 H510 R618 F713
BS03	MG	A	Q735 L987	Q482 L734
BS04	MG	A	D760 H763 H962	D507 H510 H709

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003723 RNA binding

External links

• PDB: RCSB:7kx9, PDBe:7kx9, PDBj:7kx9
• PDBsum: 7kx9
• PubMed: 34471284
• UniProt: D5MRY8