Structure of PDB 7kx8 Chain A

Receptor sequence
>7kx8A (length=263) Species: 9606 (Homo sapiens) [Search protein sequence]
IPATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCREHMI
QNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDYTERDASG
MLYNLASAIKYLHSLNIVHRDIKPENLLVYEKSLKLGDFGLATIVDGPLY
TVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSQEVLF
DQILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVN
HQLSVAGKIKKHF
3D structure
PDB7kx8 Structural basis for small molecule targeting of Doublecortin Like Kinase 1 with DCLK1-IN-1.
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 X8J A I396 V404 A417 M465 V468 K469 L518 I15 V23 A36 M82 V85 K86 L128 BindingDB: IC50=3.0nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7kx8, PDBe:7kx8, PDBj:7kx8
PDBsum7kx8
PubMed34545159
UniProtO15075|DCLK1_HUMAN Serine/threonine-protein kinase DCLK1 (Gene Name=DCLK1)

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