Structure of PDB 7kwo Chain A

Receptor sequence
>7kwoA (length=1200) Species: 9606 (Homo sapiens) [Search protein sequence]
ATRRYYLGAVELSWDYMVYKKTLFVEFTDHLFNIAKPRPPWMGLLGPTIQ
AEVYDTVVITLKNMASHPVSLHAVGVSYWKASEGAEYDDQTSQREKEDDK
VFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSHVDLVKDLNSGLIGALL
VCREGSLHKFILLFAVFDEGKSWHSEWPKMHTVNGYVNRSLPGLIGCHRK
SVYWHVIGMGTTPEVHSIFLEGHTFLVRNHRQASLEISPITFLTAQTLLM
DLGQFLLFCHISSHQHDGMEAYVKVDSCPKTWVHYIAAEEEDWDYAPLVL
ASYKSQYLNNGPQRIGRKYKKVRFMAYTDETFKTREAIQHESGILGPLLY
GEVGDTLLIIFKNQASRPYNIYPHGITDVRPLYKHLKDFPILPGEIFKYK
WTVTVEDGPTKSDPRCLTRYYSSFVNMERDLASGLIGPLLICYKRNVILF
SVFDENRSWYLTENIQRFLPNPAGVQLEDPEFQASNIMHSINGYVFDSLQ
LSVCLHEVAYWYILSIGAQTDFLSVFFSGYTFKHKMVYEDTLTLFPFSGE
TVFMSMENPGLWILGCHNSDFRNRGMTALLKVSSCEDFDIYDKKTRHYFI
AAVERLWDYGMSSSVPQFKKVVFQEFTDGSFTQPLYRGELNEHLGLLGPY
IRAEVEDNIMVTFRNQASRPYSFYSSLISYEPRKNFVKPNETKTYFWKVQ
HHMAPTKDEFDCKAWAYFSDVDLEKDVHSGLIGPLLVCHTNTLNPAHGRQ
VTVQEFALFFTIFDETKSWYFTENMERNCRPTFKENYRFHAINGYIMDTL
PGLVMAQDQRIRWYLLSMGSNENIHSIHFSGHVFTVRKKEEYKMALYNLY
PGVFETVEMLPSKAGIWRVECLIGEHLHAGMSTLFLVYSNKCQTPLGMAS
GHIRDFQITASGQYGQWAPKLARLHYSGSINAWSTKEPFSWIKVDLLAPM
IIHGIKTQGARQKFSSLYISQFIIMYSLDGKKWQTYRGNSTGTLMVFFGN
VDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCDLNSCSMPLG
MESKAISDAQITASSYFTNMFATWSPSKARLHLQGRSNAWRPQVNNPKEW
LQVDFQKTMKVTGVTTQGVKSLLTSMYVKEFLISSSQDGHQWTLFFQNGK
VKVFQGNQDSFTPVVNSLDPPLLTRYLRIHPQSWVHQIALRMEVLGCEAQ
3D structure
PDB7kwo Molecular determinants of the factor VIII/von Willebrand factor complex revealed by BIVV001 cryo-electron microscopy.
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A K107 E122 D125 D126 K80 E95 D98 D99
BS02 ZN A H267 C310 H315 H216 C259 H264
BS03 CU A C2000 I2002 H2005 C871 I873 H876
Gene Ontology
Molecular Function
GO:0005507 copper ion binding
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:7kwo, PDBe:7kwo, PDBj:7kwo
PDBsum7kwo
PubMed33569592
UniProtP00451|FA8_HUMAN Coagulation factor VIII (Gene Name=F8)

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