Structure of PDB 7kue Chain A

Receptor sequence
>7kueA (length=290) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
EYTKEKKVGEGTYAVVYLGCKIAIKEIKTSKDGLDMSAIREVKYLQEMQH
PNVIELIDIFMAYDNLNLVLEFLPTDLEVVIKDKSILFTPADIKAWMLMT
LRGVYHCHRNFILHRDLKPNNLLFSPDGQIKVADFGLARAIPAPHEILTS
NVVTRWYRAPELLFGAKHYTSAIDIWSVGVIFAELMLRIPYLPGQNDVDQ
MEVTFRALGTPTDRDWPEVSSFMTYNKLQIYPPPSRDELRKRFIAASEYA
LDFMCGMLTMNPQKRWTAVQCLESDYFKELPPPSDPSSIK
3D structure
PDB7kue Structure of TFIIK for phosphorylation of CTD of RNA polymerase II.
ChainA
Resolution3.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D129 K131 N134 D147 I160 T167
Catalytic site (residue number reindexed from 1) D116 K118 N121 D134 I147 T154
Enzyme Commision number 2.7.11.23: [RNA-polymerase]-subunit kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A L83 E84 F85 K131 N134 D147 L70 E71 F72 K118 N121 D134
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity
Biological Process
GO:0006289 nucleotide-excision repair
GO:0006355 regulation of DNA-templated transcription
GO:0006360 transcription by RNA polymerase I
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0006370 7-methylguanosine mRNA capping
GO:0006468 protein phosphorylation
GO:0006995 cellular response to nitrogen starvation
GO:0009891 positive regulation of biosynthetic process
GO:0010508 positive regulation of autophagy
GO:0016310 phosphorylation
GO:0032968 positive regulation of transcription elongation by RNA polymerase II
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051301 cell division
GO:0051726 regulation of cell cycle
GO:1905866 positive regulation of Atg1/ULK1 kinase complex assembly
Cellular Component
GO:0005634 nucleus
GO:0005675 transcription factor TFIIH holo complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070985 transcription factor TFIIK complex
GO:1902554 serine/threonine protein kinase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7kue, PDBe:7kue, PDBj:7kue
PDBsum7kue
PubMed33827808
UniProtP06242|KIN28_YEAST Serine/threonine-protein kinase KIN28 (Gene Name=KIN28)

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