Structure of PDB 7ku7 Chain A

Receptor sequence
>7ku7A (length=269) Species: 269446 (Rous sarcoma virus (strain Schmidt-Ruppin A)) [Search protein sequence]
PLREAKDLHTALHIGPRALSKACNISMQQAREVVQTCPHCNSAPALEAGV
NPRGLGPLQIWQTDFTLEPRMAPRSWLAVTVDTASSAIVVTQHGRVTSVA
VQHHWATAIAVLGRPKAIKTDNGSCFTSKSTREWLARWGIAHTTGIPGNS
QGQAMVERANRLLKDKIRVLAEGDGFMKRIPTSKQGELLAKAMYALNHFE
RGENTKTPIQKHWRPTVLTEGPPVKIRIETGEWEKGWNVLVWGRGYAAVK
NRDTDKVIWVPSRKVKPDI
3D structure
PDB7ku7 Cryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome.
ChainA
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A G49 V50 N51 T143 T144 G145 I146 Q151 A154 R158 L162 E203 R244 Y246 G49 V50 N51 T143 T144 G145 I146 Q151 A154 R158 L162 E203 R244 Y246
BS02 dna A E157 N160 R161 E157 N160 R161
BS03 ZN A H9 H13 C37 C40 H9 H13 C37 C40
BS04 MG A D64 E157 D64 E157
BS05 MG A D64 D121 D64 D121
BS06 ZZX A D64 S150 E157 D64 S150 E157
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:7ku7, PDBe:7ku7, PDBj:7ku7
PDBsum7ku7
PubMed33712691
UniProtP03354|POL_RSVP Gag-Pol polyprotein (Gene Name=gag-pol)

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