Structure of PDB 7krx Chain A

Receptor sequence
>7krxA (length=308) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence]
IKVFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKPHNSHEGKT
FYVLPNDDTLRVEAFEYYHTTDPSFLGRYMSALNHTKKWKYPQVNGLTSI
KWADNNSYLATALLTLQQIELKFNPPALQDAYYRARAGEAANFCALILAY
CNKTVGELGDVRETMSYLFQHANLDSCKRVLNVVCKTCGQQQTTLKGVEA
VMYMGTLSYEQFKKGVQIPCTCQATKYLVQQESPFVMMSAPPAQYELKHG
TFTCASEYTGNYQCGHYKHITSKETLYCIDGALLTKSSEYKGPITDVFYK
ENSYTTTI
3D structure
PDB7krx The crystal structure of Papain-Like Protease of SARS CoV-2, C111S mutant, in complex with PLP_Snyder441
ChainA
Resolution2.72 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y41 A G163 D164 P248 Y264 Y268 Q269 T301 G159 D160 P242 Y258 Y262 Q263 T295
BS02 ZN A C192 C224 C226 C188 C220 C222
BS03 ZN A H17 E67 H13 E63
BS04 ZN A H89 D108 H85 D104
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7krx, PDBe:7krx, PDBj:7krx
PDBsum7krx
PubMed
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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